Services

TMIC offers custom tailored metabolomics services that are many times faster, more quantitative, and far more comprehensive than any other facility in North America and provides a single source destination for fee-for-service metabolic profiling including comprehensive metabolite identification, quantification, and analysis for the medical, agricultural, food processing (including functional food and nutraceutical) as well as the environmental testing markets.

Check out our brochure for more information on metabolomics services.

Available Technical Services

TMIC offers the following technical services for the analysis of biofluids, tissues, bioproducts, bioprocesses, or crops by GC-MS, LC-MS, NMR, HPLC and combined approaches:

Lipidomics (phospholipids, TAGs, DAGs, MAGs, CEs, and fatty acids)
Phytochemical analysis
Nutrients (general metabolite analysis)
Metabolic footprinting and fingerprinting
Food composition analysis
Biofuel composition analysis
Tissue imaging
Free bioinformatics tools

TMIC has extensive experience working with many types of samples and model organisms. If your organism or sample type does not appear on these lists, please contact us to see if we can still accommodate your needs. See here for more details on our available equipment.

We also provide comprehensive reports including metabolite identification and concentration, experimental and quality control methods, and statistical analysis.

Services

Untargeted Metabolomic Profiling - MS Imaging

Service

Number of compounds

Price (CAD) / sample

Volume

Lipidomics by MALDI-MS Tissue imaging

900

Academic/Government: $900 per sample

Whole organs or tissues

Primary metabolites by MALDI-MS Tissue imaging

Academic/Government: $600 per sample

Whole organs or tissues

Platform Specific Metabolomic Assays - Absolute Quantitative Assays

Service

Number of compounds

Price (CAD) / sample

Volume

Direct Flow Injection Mass Spectrometry (DI-MS)

Up to 180

Academic/Government: $115

Industry: $160

30 - 50 µL

Direct Flow Injection Mass Spectrometry for Metabolites and Lipids

400

Academic: $135

Industry: $180

30 - 50 uL

Quantitative GC-MS

30-40

Academic/Government: $70

Industry: $144

100 µL

Quantitative Lipidomics

Academic/Government: $400

Industry: $600

Please inquire

Quantitative Metabolomics by CE-MS

Up to 250

Academic/Government: $125

Industry: $200

50 µL (as low as 5 µL depending on sample) or 10 mg (dried weight for tissue biospies)

Quantitative NMR Spectroscopy

50 - 220

Academic/Government:

Serum and plasma: $50
Other samples: $125/sample

Industry:

Serum and plasma: $75
Other samples: $180

300 - 500 µL

TMIC Prime Metabolomics Profiling Assay

143

Academic: $60

Industry: $100

80 - 100 µL

Targeted metabolomic profiling in complex mixtures GC×GC-TOFMS (EI only)

Depends very heavily on sample, number of targets an elution times of target(s).

Please inquire

Global (Untargeted) Metabolomic Profiling - Untargeted Assays

Service

Number of compounds

Price (CAD) / sample

Volume

Chemical isotope labeling 1 D LC-MS

Accurate relative quantification of up to 2,500 metabolites (not features) in urine or 1,500 in blood or 1,000 in plant extract or 1,500 in cell extracts using one chemical-group labeling LC-MS.

Academic/Government:

$130 per one labeling LC-MS (duplicate analyses per sample)*
$75/hour for data analysis

* Up to four labeling methods can be applied to the same sample for the analysis of 1) amines/phenols, 2) carboxylic acids, 3) hydroxyls, and 4) ketones/aldehydes, separately. The combined results of these four submetabolomes can cover over 5,000 to 10,000 metabolites (sample depedent) per sample. A user can choose the labeling method(s) to analyze one or more chemical-group-based submetabolomes. Positive metabolite identification of 100 to 400 metabolites (sample dependent) based on retention time and accurate mass matches to labeled standard libraries is included in the analysis. The remaining metabolites are putatively matched to chemical structures in metabolome databases.

Industry:

$312 per one labeling LC-MS (duplicate analyses per sample)
$180/hour for data analysis

20-100 µL or 1-5 mg lyophilized powder

Chemical isotope labeling 2 D LC-MS

Up to 10,000 putative metabolites in urine or up to 8,000 in blood. Please contact us for other types of samples

Academic/Government:

$3000 (based on running 25 fractions; the price will be reduced if less fractions are analyzed at the expense of less number of putative metabolites)
$75/hour for data analysis

Industry:

$5880
$180/hour for data analysis

40-200 µL or 20-100 mg lyophilized powder

Metabolite identification by online CE-MS/MS

Sample dependent

Academic/Government:

$300 (1st sample)
$150 for 2 CE-MS runs per sample
$75/hour for data analysis
Prices will be pro-rated based on total sample size

Industry:

$500 (1st sample)
$250 for 2 CE-MS runs per sample
$150/hour for data analysis

50 µL (as low as 5 µL depending on sample) or 10 mg (dried weight for tissue biospies)

Untargeted Lipidomics by 1D UPLC-MS

>2000

Academic/Government:

$400 (1st sample)
$120 for 2 UPLC-MS runs per sample
$75/hour for data analysis

Industry:

$800 (1st sample)
$240 for 2 UPLC-MS runs per sample
$150/hour for data analysis

50 µL

Untargeted Lipidomics by RPLC-QTOF-MS and MS/MS

>4000 features

Academic/Government:

$140 for 2 RPLC-MS runs per sample (relative quantification)
$280 for 2 RPLC-MS/MS runs per study (lipid identification)
$75/hour for data analysis

Industry:

$336 per sample (relative quantification)
$672 per study (metabolite identification)
$180/hour for data analysis

20-200 µL or 10-50 mg lyophilized powder

Untargeted Metabolomics by RPLC-QTOF-MS and MS/MS

>5000 features

Academic/Government:

$140 for 2 RPLC-MS runs per sample (relative quantification);
$280 for 2 RPLC-MS/MS runs per study (metabolite identification)
$75/hour for data analysis

Industry:

$336 per sample (relative quantification)
$672 per study (metabolite identification)
$180/hour for data analysis

20-200 µL or 10-50 mg lyophilized powder

Untargeted metabolomics by GC×GC-TOFMS (EI only). Sample introduction options include liquid, SPME, direct headspace, thermal desorption

>2000

Academic/Government:

$200 + sample prep
$75/hour for data analysis

Industry:

-$400 + sample preparation assuming standard GC×GC column configuration works – i.e. no custom method development - $180/hour for data analysis

Untargeted metabolomics by UPLC-FT-MS

6000 - 10000

Academic/Government:

$400 (1st sample)
$120 for 2 UPLC-MS runs per sample
$240 for 4 UPLC-MS runs per sample
$75/hour for data analysis

Industry:

$800 (1st sample)
$240 for 2 UPLC-MS runs per sample
$480 for 4 UPLC-MS runs per sample
$150/hour for data analysis

75 µL

Targeted Metabolomic Profiling - Class Specific Assays

Service

Number of compounds

Price (CAD) / sample

Volume

2nd nucleotide messengers analysis

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

2x10(6) cells or 50mg tissues

Acyl CoAs Analysis

Academic/Government: $55

Industry: $90

200 µL

Aldehydes analysis

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

100 µL plasma/serum and 0.5 mL urine

Anthocyanin/ Chlorophyll Analysis

Academic/Government: $55

Industry: $90

200 µL

Bile acid synthesis precursors analysis

Academic/Government

$200 (1st sample)
$60 for each additional sample

Industry:

$400 (1st sample)
$120 for each additional sample

50 µL plasma/serum, 2x10(6) cells or 50mg tissues

Bile acids analysis (I)

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

25 µL plasma/serum, 1 uL bile, 200 uL urine, 2x10(6) cells or 20 mg tissues

Bile acids analysis (II)

Academic/Government:

$400 (1st sample)
$150 for each additional sample

Industry:

$800 (1st sample)
$300 for each additional sample

25 µL plasma/serum, 1 uL bile, 200 uL urine, 2x10(6) cells or 20 mg tissues

Bile acids analysis (III)

Academic/Government: $110

Industry: $155

50 µL

Cardiolipin compounds analysis

Academic/Government:

$400 (1st sample)
$120 for 2 UPLC-MS runs per sample

Industry:

$800 (1st sample)
$240 for 2 UPLC MS runs per sample

100 µL plasma/serum, 2x10(6) cells or 50mg tissues

Carotenoid Analysis

Academic/Government: $55

Industry: $90

200 µL

Catecholamines

Academic: $40/sample

Industry: $60/sample

50-100 µL

Free and acyl CoAs analysis

Academic/Government:

$400 (1st sample)

50 mg tissues, 1x10(7) cells

Full-profile fatty acids analysis

Academic/Government

$400 (1st sample)

50 μL palsma/serum, 20 mg tissues

In vivo metabolites of vitamin co-metabolism

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

200 µL urine, 50 mg tissues, 1x10(7) cells

Low-MW sugars analysis

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

50 µL plasma/serum, 2x10(6) cells or 50mg tissues

Meat Biomarkers

Academic/Government:$75

Industry: $108

200 µL

Metal Analysis (Metallomics)

40-50

Academic/Government: $35

Industry: $54

200 µL

Nucleoside/Nucleotide Analysis

Academic/Government: $55

Industry: $90

200 µL

Plant Phytohormones analysis

Academic:

$400 for the first sample
$120 for each additional sample.

Industry:

$800 for the first sample
$240 for each additional sample.

100-300 mg, depending on tissue. Please inquire.

Polyphenol Analysis

Academic/Government: $55

Industry: $90

200 µL

Short-chain (C2 to C6) fatty acids analysis

Academic/Government:

$200 (1st sample)
$60 for each additional sample

Industry:

$400 (1st sample)
$120 for each additional sample

50 μL palsma/serum, 20 mg tissues

Steroid hormones analysis

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

100 µL plasma/serum, 100 mg tissues

Thiol Analysis

Academic/Government: $55

Industry: $90

200 µL

Uremic Toxins Assay

Please inquire

100 uL

Urine Organic Acids

115 (sample dependent)

Academic/Government: $70

Industry: $144

200 µL

Vitamin Analysis - Fat soluble

Academic/Government:$75

Industry: $108

200 µL

Vitamin Analysis - Water soluble

Academic/Government:$75

Industry: $108

200 µL

Volatiles and semi-volatiles profiling by SPME GC×GC-TOFMS (EI only)

>2000

Academic/Government:

$200 + sample prep
$75/hour for data analysis

Industry:

$400 + sample preparation assuming standard GC×GC column configuration works – i.e. no custom method development
$180/hour for data analysis

Targeted Metabolomic Profiling - Pathway Specific Assays

Service

Number of compounds

Price (CAD) / sample

Volume

Amino acid metabolism/urea cycle metabolism

>50

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

50 µLplasma/serum, 2x10(6) cells, 2x10(5) neurons or 50mg tissues

Central carbon metabolism

>60

Academic/Government:

$400 (1st sample)
$180 for each additional sample

Industry:

$800 (1st sample)
$360 for each additional sample

2x10(6) cells/50mg tissues

Fatty acid metabolism - Medium-to long-chain fatty acids and carnitines analysis

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

50 µL plasma/serum, 2x10(6) cells, 2x10(5) neurons or 50mg tissues

Mevalonate Pathway and isoprenoids/cholesterol synthesis

Academic/Government:

$400 (1st sample)
$180 for each additional sample

Industry:

$800 (1st sample)
$360 for each additional sample

50 mg tissues, 1x10(7) cells

One-carbon metabolism

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

2x10(6) cells/50mg tissues

One-carbon metabolism

Academic/Government: $75

Industry: $108

200 µL

Purine-pyrimidine metabolism pathway

100

Academic/Government:

$400 (1st sample)
$120 for each additional sample

Industry:

$800 (1st sample)
$240 for each additional sample

200 µL urine, 50 mg tissues, 1x10(7) cells

Sphingolipid pathway-precursors, intermediates and end-product sphingolipids

100

Academic/Government:

$400 (1st sample)
$120 for 2 UPLC-MS runs per sample

Industry:

$800 (1st sample)
$240 for 2 UPLC-MS runs per sample

50 µLplasma/serum, 2x10(6) cells, 2x10(5) neurons or 50mg tissues

Bioinformatics Support

Service

Number of compounds

Price (CAD) / sample

Volume

Analysis of your data or study design consultation

Please inquire

Specialized Services

Service

Number of compounds

Price (CAD) / sample

Volume

Methods Development

Please inquire

Please note:

All prices quoted are in Canadian Dollars (CAD).
Researchers from the public sector receive ‘Academic pricing’.
Large projects involving a combination of 3 or more services may be eligible for discounts of 10‐15%.

TMIC’s pricing model is in accordance with the Genome Canada Access policy for the Genomics Innovation Network:

Where the users are researchers from the public sector, pricing will be based only on the variable costs of providing the service (e.g., consumables, technicians’ salaries and consultation time)
Where the users are researchers from the private sector, full cost‐recovery is required, and the pricing will be based on both the variable costs as described above, and other direct costs such as overhead, amortization expense related to equipment costs, etc. Institutional overhead rates also apply to private sector projects.
Prices are set using the above criteria as guidelines. Variations in prices may be due to the type of relationship between the user and TMIC (collaborative or fee‐for‐service), the level of interaction required (e.g., with or without post data‐generation analysis), and the magnitude of the request which may benefit from volume cost savings. TMIC is not able to provide services to any users (collaborative or fee‐for‐service) at prices below the variable cost of the service as defined above.