Mevalonate Pathway and Isoprenoids/Cholesterol Synthesis

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Description

Detection and quantitation of isoprenyl phosphate intermediates, isoprenoids (ubiquinones, dolichols, vitain K2 and squalene, etc.), cholesterol and other sterols by UPLC-MRM/MS and UPLC-FTMS

Quantitative

Absolute

Platform Available

UPLC-MRM/MS

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Name	HMDB ID	Super Class	Class
3-Hydroxy-3-methylglutaryl CoA (HMG-CoA)
Dolichols ( 13 to 21 isoprene units)
Isopentenyl pyrophosphate
Lathostenol
Menoquinones (vitamin Ks)
Mevalonic acid 5-phosphate
Ubiquinones ---CoQ6, CoQ8, CoQ9, CoQ10, CoQ11, CoQ12
2,3-oxidosqualene		Lipids and lipid-like molecules	Prenol lipids
7-Dehydrocholesterol (provitamin D3)		Lipids and lipid-like molecules	Steroids and steroid derivatives
7-Dehydrodesmosterol		Lipids and lipid-like molecules	Steroids and steroid derivatives
Acetoacetyl-CoA		Lipids and lipid-like molecules	Fatty Acyls
Acetyl-CoA		Lipids and lipid-like molecules	Fatty Acyls
Cholesterol	HMDB00067	Lipids and lipid-like molecules	Steroids and steroid derivatives
Desmosterol	HMDB0002719	Lipids and lipid-like molecules	Steroids and steroid derivatives
Dihydrolanosterol		Lipids and lipid-like molecules	Prenol lipids
Dimethylallyl pyrophosphate		Lipids and lipid-like molecules	Prenol lipids
Farnesyl pyrophosphate		Lipids and lipid-like molecules	Prenol lipids
Geranyl pyrophosphate		Lipids and lipid-like molecules	Prenol lipids
Geranylgeranyl pyrophosphate		Lipids and lipid-like molecules	Prenol lipids
Lanosterol		Lipids and lipid-like molecules	Prenol lipids
Mevalonic acid	HMDB0059629	Lipids and lipid-like molecules	Fatty Acyls
Squalene		Lipids and lipid-like molecules	Prenol lipids
Zymostenol		Lipids and lipid-like molecules	Steroids and steroid derivatives
Zymosterol		Lipids and lipid-like molecules	Steroids and steroid derivatives
Mevalonic acid 5-pyrophosphate		Organic oxygen compounds	Organic oxoanionic compounds