Fast, quantitative, comprehensive!

Services

TMIC is North America’s premiere single source destination providing fee-for-service metabolic profiling. We offer a broad range of custom metabolomics services to fill any need. If you want the fastest, most quantitative and comprehensive metabolomics facility on the continent, you’re at the right place.

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Science!

Science

Metabolomics is an emerging field of "omics" research specializing in the near global analysis of small molecule metabolites found in living organisms. Its applications are already being seen in a broad range of disciplines including disease diagnostics, agriculture food and safety, and pharmaceutical R&D.

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Software!

Software

Vital to metabolomics research is the ability to share it with the wider community. Since 2006, the Wishart lab at the University of Alberta has made its research publicly available, developing metabolomic databases, programs and web servers accessed by researchers and private sector partners worldwide.

Available software »


Scientists find simple urine test could offer a non-invasive approach for diagnosis of IBS patients

Urine Test for IBS Patients

August 28, 2019

A recent study by TMIC’s Britz-McKibbin Research Group at McMaster University has identified new biomarkers for Irritable Bowel Syndrome (IBS) after comparing the metabolite profiles of urine samples from a cohort of IBS patients to a control group of healthy adults.

Speaking on the study’s findings, lead author Dr. Philip Britz-McKibbin commented, “We were interested in finding if there is a better way to detect and monitor IBS that avoids invasive colonoscopy procedures while also giving us better insights into its underlying mechanisms.”

In addition to the study, the Britz-McKibbin Research Group is currently expanding its research to discover new biomarkers in urine that can differentiate Crohn’s disease from ulcerative colitis in children. The group aims to avoid future colonoscopies altogether, and hopes that their research may allow for rapid screening of various chronic gut disorders more accurately and at a lower cost.

Visit McMaster University’s Brighter World blog to find out more about the study


Multiplexed LC–ESI–MRM‐MS‐based Assay for Identification of Coronary Artery Disease Biomarkers in Human Plasma

Biomarkers for Coronary Artery Disease

August 28, 2019

Featured on the back cover of Proteomics – Clinical Applications, Dr. Christoph Borchers’ newest publication focuses on the identification of biomarkers specific to coronary artery disease (CAD). Along with a group of BC scientists, including researchers from the University of Victoria and University of British Columbia, Dr. Borchers helped develop an LC-ESI-MS based assay that can measure 107 stable isotope labeled peptide standards and native peptides in tryptic digests of plasma.

After extensive computational and statistical analysis of samples from subjects with and without angiographic evidence of CAD, the assay revealed six plasma proteins associated with the disease. If the results of the study are externally validated, the assay and identified biomarkers can improve CAD risk stratification in patients.

Check out the full featured article in Volume 13, Issue 4 of Proteomics – Clinical Applications


Thermodynamics-based retention maps to guide column choices for comprehensive multi-dimensional gas chromatography

Thermodynamics-based retention maps

August 28, 2019

Published in Analytica Chimica Acta, Dr. James Harynuk’s latest publication looks at optimizing the design and development of new two-dimensional gas chromatography (GCxGC) methods using secondary columns. The inclusion of these columns can enhance the separation power over one-dimensional GC methods and improve ultimate separation quality. However, the choices of stationary phase chemistries, geometries and configurations must also be assessed before changing the instrument design.

Previously, these choices were made using educated guesses, literature searches, or trial and error. In this article, Dr. Harynuk proposes a new thermodynamic model for GC separations which uses characteristic thermodynamic parameters to create retention maps. These maps provide a fast and easy way of acquiring information that can inform choices of column chemistries, phase ratios and configurations.

Dr. Harynuk also points out that although these retention maps were used to evaluate two-dimensional GC separations, they can be easily extended to evaluate three-dimensional (GCxGCxGC) separations as well.

Read the full article online in Analytica Chimica Acta via ScienceDirect


JoVE Methods Collection Highlights: Protein-Protein Interactions

Britz-McKibbin

August 28, 2019

A recent video in the Journal of Visualized Experiments (JoVE) from one of TMIC’s project leaders, Dr. Michael Overduin, and Dr. Alastair Barr (University of Westminster) evaluates the merits and limitations of several techniques studying protein-protein interactions (PPIs). PPIs are fundamental to the generation of biological effects, with many PPIs being intimately linked with disease and used as targets for drug action.

The video covers several methods for studying PPIs, including widely used techniques such as coimmunoprecipitation and affinity purification, as well as narrower techniques specific to certain protein structures. While Dr. Overduin and Dr. Barr conclude that no one technique is best due to the wide diversity of PPIs, they do highlight the emerging technique of spatial proteomics, which has been successfully harnessed as a discovery tool to unravel complex disease mechanisms.

Watch the full video to learn more about protein-protein interactions and the methods used to study them


Research opens up possibility of saliva test for Alzheimer's Disease

Saliva Test for Alzheimers

August 28, 2019

In a recent interview with the Edmonton Journal, TMIC’s own Dr. Liang Li and University of Alberta psychology professor Dr. Roger Dixon discussed their latest research into the early detection of Alzheimer’s disease. Taking a non-invasive approach, Li and Dixon examined the saliva samples of 109 patients who were grouped according to whether they had Alzheimer’s disease, mild cognitive impairment, or neither.

After analyzing over 6,000 metabolites in the samples using mass spectrometry, Li and Dixon were able to identify three of these compounds as biomarkers. These biomarkers can not only help doctors identify which individuals have a higher risk of developing Alzheimer’s, but also assist in the development of effective preventative measures for patients to use.

Read the full Edmonton Journal interview with Dr. Li and Dr. Dixon


Introducing the Milk Composition Database

Britz-McKibbin

August 28, 2019

The Milk Composition Database (MCDB) is a freely available online resource containing detailed information about small molecule metabolites found in cow’s milk. Developed by TMIC’s Wishart Research Group, MCDB contains a complete list of metabolite names, structures, level of verification, reference spectra and citations for all of the milk compounds that have ever been identified, quantified or reported in either this database or existing scientific literature.

MCDB currently contains 2,355 metabolite entries, including water and lipid-soluble metabolites as well as metabolites that would be regarded as either abundant (>1 uM) or relatively rare (<1 nM). Each metabolite entry contains more than 90 data fields, and many of them are hyperlinked to other databases (including PubChem and DrugBank, among others) as well as a variety of structure and pathway viewing applets. In addition, MCDB is fully searchable and supports text, mass, spectral and structure searches.

Check out the MCDB!