Services


Tmic3

TMIC offers custom tailored metabolomics services that are many times faster, more quantitative, and far more comprehensive than any other facility in North America and provides a single source destination for fee-for-service metabolic profiling including comprehensive metabolite identification, quantification, and analysis for the medical, agricultural, food processing (including functional food and nutraceutical) as well as the environmental testing markets.

Available Technical Services

TMIC offers the following technical services for the analysis of biofluids, tissues, bioproducts, bioprocesses, or crops by GC-MS, LC-MS, NMR, HPLC and combined approaches:

  • Lipidomics (phospholipids, TAGs, DAGs, MAGs, CEs, and fatty acids)
  • Phytochemical analysis
  • Nutrients (general metabolite analysis)
  • Metabolic footprinting and fingerprinting
  • Food composition analysis
  • Biofuel composition analysis
  • Tissue imaging
  • Free bioinformatics tools

TMIC has extensive experience working with many types of samples and model organisms. If your organism or sample type does not appear on these lists, please contact us to see if we can still accommodate your needs. See here for more details on our available equipment.

TMIC provides comprehensive reports including metabolite identification and concentration, experimental and quality control methods, and statistical analysis. Take a look here at what your TMIC results and report would look like.


Platform Specific Metabolomic Assays - Absolute Quantitative Assays

Number of compounds is estimated, but varies depending on sample type
ServiceNumber of compoundsPrice/sampleVolume
Direct Flow Injection Mass Spectrometry (DI-MS)Up to 180

Canadian Academic/Government: $65

Industry: $85

30-50 µL
Quantitative NMR Spectroscopy50-220

Canadian Academic/Government:
- Serum and CSF: $75
- Urine and other biofluids: $125/sample

Industry:
- Serum and CSF: $90 + 20% UofA Overhead
- Urine and other biofluids: $150

500 µL
Quantitative GC-MS30-40

Canadian Academic/Government: $70

Industry: $120

100 µL
Quantitative GC-MS/MS (EI, PCI, NCI available)30-40

Canadian Academic/Government:
$280 (1st sample)
$90 (each additional sample)

Industry:
$350 (1st sample)
$110 (each additional sample)

100 µL
Quantitative GC/GC-MS/MS (EI, PCI, NCI available)Depends very heavily on sample, number of targets and elution times of target(s)

Canadian Academic/Government:
$480 (1st sample)
$110 (each additional sample)

Industry:
$600 (1st sample)
$110 (each additional sample)

Please inquire
Targeted metabolomic profiling in complex mixtures GC×GC-TOFMS (EI only)Depends very heavily on sample, number of targets an elution times of target(s).

Canadian Academic/Government:
$480 (1st sample)
$110 (each additional sample)

Industry:
$600 (1st sample)
$110 (each)

Please inquire
Quantitative LipidomicsUp to 2000

Canadian Academic/Government:
$400

Industry: $500

Please inquire

Global (Untargeted) Metabolomic Profiling - Untargeted Assays

Number of compounds is estimated, but varies depending on sample type
ServiceNumber of compoundsPrice/sampleVolume
Untargeted metabolomics by GC-MS (EI only)25-80

Canadian Academic/Government:
$2,800 + sample preparation (assuming 100 samples and 2 classes)

Industry: $3,500 + sample preparation (assuming 100 samples and 2 classes)

Please inquire
Untargeted metabolomics by GC×GC-TOFMS (EI only)>2000

Canadian Academic/Government: $200 + sample prep, $75/hour for data analysis

Industry: $350 + sample preparation assuming standard GC×GC column configuration works – i.e. no custom method development, $150/hour for data analysis

Please inquire
Untargeted metabolomics by UPLC-FT-MS>2000

Canadian Academic/Government: $400 (1st sample)
$120 for 2 UPLC-MS runs per sample
$240 for 4 UPLC-MS runs per sample
$75/hour for data analysis

Industry:
$800 (1st sample)
$240 for 2 UPLC-MS runs per sample
$480 for 4 UPLC-MS runs per sample
$150/hour for data analysis

75 µL
Untargeted Metabolomics by RPLC-QTOF-MS and MS/MS>5000 features

Canadian Academic/Government:
$140 for 2 RPLC-MS runs per sample (relative quantification);
$280 for 2 RPLC-MS/MS runs per study (metabolite identification)
$75/hour for data analysis

Industry:
$280 per sample (relative quantification)
$560 per study (metabolite identification)
$150/hour for data analysis

20-200 µL or 10-50 mg lyophilized powder
Untargeted Lipidomics by RPLC-QTOF-MS and MS/MS>4000 features

Canadian Academic/Government: $140 for 2 RPLC-MS runs per sample (relative quantification);
$280 for 2 RPLC-MS/MS runs per study (lipid identification)
$75/hour for data analysis

Industry:
$280 per sample (relative quantification);
$560 per study (metabolite identification)
$150/hour for data analysis

20-200 µL or 10-50 mg lyophilized powder
Untargeted metabolomics by DI-FTICR-MS>1000

Canadian Academic/Government:
$400 (1st sample)
$90 per ion mode per sample (i.e. $180 per sample for (+) and (-) ESI modes)

Industry:
$800 (1st sample)
$180 per ion mode per sample (i.e. $360 per sample for (+) and (-) ESI modes)

75 µL
Untargeted metabolomics by isotope labeling 1 D LC-MSUp to 2,500 putative metabolites in urine or 1,500 in blood or 1,000 in plant extracts or 1,500 in cell extracts

Canadian Academic/Government: $120
$75/hour for data analysis

Industry: $240
$150/hour for data analysis

20-100 µL or 10-50 mg lyophilized powder
Untargeted metabolomics by isotope labeling 2 D LC-MSUp to 10,000 putative metabolites in urine or up to 8,000 in blood. Please contact us for other types of samples

Canadian Academic/Government:
$3000 (based on running 25 fractions; the price will be reduced if less fractions are analyzed at the expense of less number of putative metabolites)
$75/hour for data analysis

Industry:
$4900
$150/hour for data analysis

40-200 µL or 20-100 mg lyophilized powder
Untargeted Lipidomics by 1D UPLC-MS>800

Canadian Academic/Government:
$400 (1st sample)
$120 for 2 UPLC-MS runs per sample
$75/hour for data analysis

Industry:
$800 (1st sample)
$240 for 2 UPLC-MS runs per sample
$150/hour for data analysis

50 µL
Metabolite identification by offline or online LC-MS/MSSample dependent

Canadian Academic/Government:
$120/compound
$75/hour for data analysis

Industry:
$240/compound
$150/hour for data analysis

Please inquire

Targeted Metabolomic Profiling - Class Specific Assays

Number of compounds is estimated, but varies depending on sample type
ServiceNumber of compoundsPrice/sampleVolume
Oxylipins Analysis18

Canadian Academic/Government:$75

Industry: $90

200 µL
Vitamin Analysis - Water soluble9

Canadian Academic/Government:$75

Industry: $90

200 µL
Vitamin Analysis - Fat soluble3

Canadian Academic/Government:$75

Industry: $90

200 µL
Endogenous vitamins and vitamin-like compounds analysis35

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample

Industry:
$800 (1st sample)
$240 for each additional sample

200 µL
Bile acids analysis (I)50

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample

Industry:
$800 (1st sample)
$240 for each additional sample

25 µL
Bile acids analysis (II)66

Canadian Academic/Government:
$400 (1st sample)
$150 for each additional sample

Industry:
$800 (1st sample)
$300 for each additional sample

25 µL
Bile acids analysis (III)20

Canadian Academic/Government: $65

Industry: $85

50 µL
Organic acids analysis40-80 (sample dependent)

Canadian Academic/Government: $70

Industry: $120

200 µL
Catecholamines analysis12

Canadian Academic/Government:
$75

Industry: $90

200 µL
Lipidomics for cardiolipinsIdentification and quantification of cardiolipin compounds by UPLC-FTMS

Canadian Academic/Government:
$400 (1st sample)
$120 for 2 UPLC-MS runs per sample

Industry:
$800 (1st sample)
$240 for 2 UPLC MS runs per sample

100 µL
Low-MW sugars analysis14

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample

Industry:
$800 (1st sample)
$240 for each additional sample

25 µL
Acylcarnitines analysisUp to 355 acylcarnitines

Canadian Academic/Government:
$200

Industry: $350

200 µL
Aldehydes analysis12

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample

Industry:
$800 (1st sample)
$240 for each additional sample

250 µL
Oxysterols analysis7

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample

Industry:
$800 (1st sample)
$240 for each additional sample

200 µL
Deoxynucleotide triphosphates (dNTPs) analysis5

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample

Industry:
$800 (1st sample)
$240 for each additional sample

Please inquire
Volatiles and semi-volatiles profiling by SPME GC×GC-TOFMS (EI only)>2000

Canadian Academic/Government:
$200 + sample prep
$75/hour for data analysis

Industry: $350 + sample preparation assuming standard GC×GC column configuration works – i.e. no custom method development
$150/hour for data analysis

Please inquire
Nucleoside/Nucleotide Analysis9

Canadian Academic/Government:
$55

Industry: $75

200 µL
Polyphenol Analysis18

Canadian Academic/Government:
$55

Industry: $75

200 µL
Anthocyanin/ Chlorophyll Analysis7

Canadian Academic/Government:
$55

Industry: $75

Please inquire
Thiol Analysis7

Canadian Academic/Government:
$55

Industry: $75

200 µL
Carotenoid Analysis6

Canadian Academic/Government:
$55

Industry: $75

200 µL
Acyl CoAs Analysis6

Canadian Academic/Government:
$55

Industry: $75

200 µL
Metal Analysis (Metallomics)40-50

Canadian Academic/Government:
$35

Industry: $45

200 µL
Lipidomics by MALDI-MS Tissue imaging Up to 850 for combined (+) and (-) ion detection

Canadian Academic/Government:
$600 for detection in (+) or (-) ion mode (i.e. $1200 for both (+) and (-) ion modes)

Industry:
$1200 for detection in (+) or (-) ion mode (i.e. $2400 for both (+) and (-) ion modes)

Please inquire
Meat Biomarkers7

Canadian Academic/Government:$75

Industry: $90

200 µL
High-value Disease Biomarker Profiling30

Canadian Academic/Government:$75

Industry: $90

200 µL

Targeted Metabolomic Profiling - Pathway Specific Assays

Number of compounds is estimated, but varies depending on sample type
ServiceNumber of compoundsPrice/sampleVolume
One-carbon metabolism 10

Canadian Academic/Government:
$75

Industry: $90

200 µL
Central carbon metabolism50

Canadian Academic/Government:
$400 (1st sample)
$180 for each additional sample

Industry:
$800 (1st sample)
$360 for each additional sample

400 µL
Amino acid metabolism/urea cycle metabolism>50

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample (includes 2 UPLC-MRM/MS methods)

Industry:
$800 (1st sample)
$240 for each additional sample (includes 2 UPLC-MRM/MS methods)

50 µL
Lipidomics for sphingolipid metabolismSample dependent – please inquire

Canadian Academic/Government:
$400 (1st sample)
$120 for 2 UPLC-MS runs per sample

Industry:
$800 (1st sample)
$240 for 2 UPLC-MS runs per sample

50 µL
Fatty acid metabolism - short- to long-chain fatty acids and acyl-carnitines analysis33 fatty acids; 21 acyl-carnitines

Canadian Academic/Government:
$400 (1st sample)
$120 for each additional sample

Industry:
$800 (1st sample)
$240 for each additional sample

50 µL

TMIC Customized assays

TMIC specializes in developing custom, quantitative LC-MS, GC-MS and NMR based assays for specific metabolomic applications, including biomarker validation. Please inquire for more information.

ServicePrice/sampleVolume
High Abundance Metabolites in Plasma/SerumPlease inquirePlease inquire
Low Abundance Metabolites in Plasma/SerumPlease inquirePlease inquire

Human Metabolome Library

Refer to http://www.hmdb.ca/hml/metabolites for a detailed list of compounds available for purchase

The Human Metabolome Library is a chemical resource with the power to help confirm, validate or quantify suspected metabolites in tissues or biofluids. The Human Library contains over 1000 compounds. Compounds are shipped in quantities of ~10mg. Please inquire for list of available compounds.

Canadian Academic and Government:

  • $25/compound for the entire library
  • $30/compound for orders less than 350 compounds
  • $35/compound for orders of 10 - 25 compounds

Industry:

  • $30/compound for the entire library
  • $35/compound for orders less than 350 compounds
  • $40/compound for orders of 10 - 25 compounds

Additional packaging and shipping costs apply. Please inquire for details.


Metabolomic Profiling Kits

Number of compounds is estimated, but varies depending on sample type
ServiceNumber of compoundsPrice/sampleVolume
NMR kit plasma/serum and CSF47 - plasma/ serum 43 - CSF

$499

Please inquire
Meat Biomarkers7Please inquirePlease inquire
High-value Disease Biomarker Profiling30Please inquirePlease inquire
MCID s008: Dns-labeling startup kitUp to 2,500 putative metabolites in urine or 1,500 in blood or 1,000 in plant extracts or 1,500 in cell extracts

$5375
$5000 (software only)

Please inquire

Metabolomic Reagents

Number of compounds is estimated, but varies depending on sample type
ServiceNumber of compoundsPrice/sampleVolume
MCID hu001: Plain human urine > 2000

$50

Please inquire
MCID hu002: Dns human urine> 2000

$50

Please inquire
MCID r009: 13C DnsCl-

$150/10 mg

Please inquire
MCID r010: 13C DmPA-

$200/10 mg

Please inquire
MCID r012: 12C DmPA-

$50

Please inquire
MCID r003: Dns-22-calibrants22

$50/10 mg

Please inquire
MCID r006-10: Dns-reagent kitUp to 2,500 putative metabolites in urine or 1,500 in blood, or 1,000 in plant extracts, or 1,500 in cell extracts

$150

Please inquire
MCID r006-50: Dns-reagent kitUp to 2,500 putative metabolites in urine or 1,500 in blood, or 1,000 in plant extracts, or 1,500 in cell extracts

$375

Please inquire
MCID r006-100: Dns-reagent kitUp to 2,500 putative metabolites in urine or 1,500 in blood, or 1,000 in plant extracts, or 1,500 in cell extracts

$750

Please inquire
MCID r007-10: DmPA-reagent kitUp to 2,500 putative metabolites in urine or 1,500 in blood or 1,000 in plant extracts or 1,500 in cell extracts

$150

Please inquire
MCID r007-50: DmPA-reagent kitUp to 2,500 putative metabolites in urine or 1,500 in blood or 1,000 in plant extracts or 1,500 in cell extracts

$375

Please inquire
MCID r007-100: DmPA-reagent kitUp to 2,500 putative metabolites in urine or 1,500 in blood or 1,000 in plant extracts or 1,500 in cell extracts

$750

Please inquire

Bioinformatics Support

ServicePrice/sampleVolume
BioinformaticsPlease inquirePlease inquire
Chemometric analysis of your data or study design consultationPlease inquirePlease inquire

Specialized Services

ServicePrice/sampleVolume
Specialized sample extractionPlease inquirePlease inquire
Specialized compound analysisPlease inquirePlease inquire
Methods DevelopmentPlease inquirePlease inquire
Metabolite identification by offline or online LC-MS/MS

Canadian Academic/Government:
$120/compound

Industry:
$240/compound

Please inquire

Please note:

  • Researchers from the public sector receive ‘Academic pricing’
  • Large projects involving a combination of 3 or more services may be eligible for discounts of 10‐15%
  • TMIC will generally analyze pilot samples free of charge. Please contact us for details.

TMIC’s pricing model is in accordance with the Genome Canada Access policy for the Genomics Innovation Network:

  • Where the users are researchers from the public sector, pricing will be based only on the variable costs of providing the service (e.g., consumables, technicians’ salaries and consultation time)
  • Where the users are researchers from the private sector, full cost‐recovery is required, and the pricing will be based on both the variable costs as described above, and other direct costs such as overhead, amortization expense related to equipment costs, etc. Institutional overhead rates also apply to private sector projects.
  • Prices are set using the above criteria as guidelines. Variations in prices may be due to the type of relationship between the user and TMIC (collaborative or fee‐for‐service), the level of interaction required (e.g., with or without post data‐generation analysis), and the magnitude of the request which may benefit from volume cost savings. TMIC is not able to provide services to any users (collaborative or fee‐for‐service) at prices below the variable cost of the service as defined above.